![]() A standard surgical technique for SLNB using CEUS has not been established. Peri-areolar injection of an ultrasound contrast agent visualized the lymphatic flow from breast to axilla, and the identification rate of SLN by CEUS (CE-SLN) was between 70% and 100%. Recently, SLNB using contrast-enhanced ultrasound (CEUS) has been reported ( 5- 10). Considering that 33% of hospitals in Japan adopt the blue dye method alone for SLNB ( 4), the development of an alternative concise and accurate SLNB method is needed. However, there are problems such as the necessity of expensive fluorescent infrared cameras and difficulty in observing detailed lymph flow with fluorescent cameras when the lymph vessels are damaged and ICG diffuses to the surroundings. To potentially compensate for this weakness of the dye method alone, a near-infrared fluorescence system using green dye (indocyanine green: ICG) to detect SLNs has been reported to be useful ( 2, 3). Actually, it has been reported that the false negative rate of SLNB is higher in the blue dye method alone than in the combination method using both blue dye and an RI ( 1). On the other hand, although the blue dye method alone does not necessitate a special facility for radiation protection, time is required to master the procedure, and missing any of the lymphatic flows produces a false-negative result when multiple lymphatic flows are present. The RI method is easy to perform and helps surgeons identify SLNs with certainty however, there are related issues, such as a limited number of facilities that can handle RIs as well as radiation exposure. Sentinel lymph nodes (SLNs) are conventionally identified using a radioisotope (RI) and blue dye. Sentinel lymph node biopsy (SLNB) for clinically node-negative breast cancer has been established as a standard minimally invasive procedure for axillary staging. contrast-enhanced ultrasonography (CEUS).one-step nucleic acid amplification (OSNA).Conclusion: “Sona-Hook” for First-SLN followed by an OSNA assay may be a feasible minimally invasive SLNB strategy. Through OSNA, qualitative assessment of tumor metastasis between First-SLNs and all SLNs completely matched together. All contrast-enhanced SLNs (CE-SLNs) were dye-positive, and the mean number of CE-SLNs sampled per patient was lower than that of dye-positive SLNs (1.48 vs. Results: In each of the 50 cases, at least one First-SLN was extracted by “Sona-Hook”. Both Sonazoid® and dye were used as tracers, and the most upstream sentinel lymph node (SLN) at each lymphatic flow detected by CEUS (First-SLN) was sampled under hookwire guidance, a procedure called “Sona-Hook”. Patients and Methods: Clinical T1-2N0M0 breast cancer patients scheduled to undergo SLNB participated in this study. Aim: To investigate the feasibility of hookwire-guided sentinel lymph node biopsy (SLNB) using contrast-enhanced ultrasonography (CEUS) followed by a one-step nucleic acid amplification (OSNA) assay.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |